期刊
NEURON
卷 33, 期 3, 页码 383-395出版社
CELL PRESS
DOI: 10.1016/S0896-6273(01)00561-X
关键词
-
资金
- NICHD NIH HHS [HD18655] Funding Source: Medline
- NINDS NIH HHS [NS28829-07] Funding Source: Medline
Transcription of the brain-derived neurotrophic factor (BDNF) gene is regulated in a calcium- and neuron-selective manner; however, the mechanisms that underlie this selectivity are not known. We have characterized a new calcium-response element, CaRE1, that is required for activity-de pendent transcription of BDNF exon III and have cloned a transcription factor, CaRF, that activates transcription from BDNF promoter III in a CaRE1-dependent manner. The transcriptional activity of CaRF is regulated in a calcium- and neuron-selective manner, suggesting that CaRF may confer selectivity upon the activity-dependent induction of BDNF exon III expression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据