期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 232, 期 1-2, 页码 225-234出版社
ELSEVIER
DOI: 10.1016/S0378-5173(01)00915-2
关键词
alginate chitosan beads; Ca2+ and Al3+ ions; sodium diclofenac; alginate/chitosan ratio; dissolution profiles
Alginate/chitosan particles were prepared by ionic gelation (Ca2+ and Al3+) for the sodium diclofenac release. The systems were characterized by electron microscopy and differential scanning calorimetry. The ability to release the active substance was examined as a function of some technological parameters and pH of dissolution medium. The release of sodium diclofenac is prevented at acidic pH. while is complete in a few minutes when pH is raised up to 6.4 and 7.2. The alginate/chitosan ratio and the nature of the gelifying cation allow a control of the release rate of the drug. The release mechanism was briefly discussed. (C) 2002 Elsevier Science B.V. All rights reserved.
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