期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 23, 期 2, 页码 71-77出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0165-6147(02)01946-6
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资金
- NIMH NIH HHS [MH20914-14] Funding Source: Medline
Abnormal signaling at corticotropin-releasing factor CRF1 and CRF2 receptors might contribute to the pathophysiology of stress-related disorders such as anxiety, depression and eating disorders, in addition to cardiac and inflammatory disorders. Recently, molecular characterization of CRF1 and CRF2 receptors and the cloning of novel ligands-urocortin, stresscopin-related peptide/urocortin II, and stresscopin/urocortin III - have revealed a far-reaching physiological importance for the family of CRF peptides. Although the physiological roles of the CRF2 receptor remain to be defined, the preclinical and clinical development of specific small-molecule antagonists of the CRF1 receptor opens new avenues for the treatment of psychiatric and neurological disorders.
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