期刊
SCIENCE
卷 295, 期 5556, 页码 821-825出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1065175
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资金
- NIGMS NIH HHS [R01 GM056264] Funding Source: Medline
- ODCDC CDC HHS [CCSG 2P30CA42014] Funding Source: Medline
The pha-4 locus encodes a forkhead box A (FoxA/HNF3) transcription factor homolog that specifies organ identity for Caenorhabditis elegans pharyngeal cells. We used microarrays to identify pharyngeal genes and analyzed those genes to determine which were direct PHA-4 targets. Our data suggest that PHA-4 directly activates most or all pharyngeal genes. Furthermore, the relative affinity of PHA-4 for different TRTTKRY (R=A/G, K=T/G, Y=T/C) elements modulates the onset of gene expression, providing a mechanism to activate pharyngeal genes at different developmental stages. We suggest that direct transcriptional regulation of entire gene networks may be a common feature of organ identity genes.
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