期刊
CURRENT OPINION IN IMMUNOLOGY
卷 14, 期 1, 页码 30-35出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S0952-7915(01)00295-3
关键词
-
类别
Antigen presenting cells (APCs) alert the immune system to attack by extracellular organisms; APCs achieve this via internalization, degradation, and display of antigenic fragments on the cell surface by MHC class 11 molecules. These class 11 molecules bind to an accessory protein, termed the invariant chain, that ensures proper folding of the molecules. Invariant-chain binding also directs class 11 molecules to lysosomes, which are probably the most important sites for antigen loading. Endosomes are intermediates in the transport of class-II-invariant chain complexes to antigen-processing compartments, whereas trafficking of class II-peptide complexes to the membrane (and beyond) is less-well understood. Unlike other APCs, dendritic cells alter their capacity to present peptides via MHC class 11 molecules during differentiation, revealing a complex level of regulated antigen-presentation by this APC subtype.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据