期刊
NATURE MEDICINE
卷 8, 期 2, 页码 121-127出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm0202-121
关键词
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资金
- NCI NIH HHS [CA9081001, CA8297601, CA90270] Funding Source: Medline
The molecular diversity of receptors in human blood vessels remains largely unexplored. We developed a selection method in which peptides that home to specific vascular beds are identified after administration of a peptide library. Here we report the first in vivo screening of a peptide library in a patient. We surveyed 47,160 motifs that localized to different organs. This large-scale screening indicates that the tissue distribution of circulating peptides is nonrandom. High-throughput analysis of the motifs revealed similarities to ligands for differentially expressed cell-surface proteins, and a candidate ligand-receptor pair was validated. These data represent a step toward the construction of a molecular map of human vasculature and may have broad implications for the development of targeted therapies.
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