期刊
SEMINARS IN IMMUNOLOGY
卷 14, 期 1, 页码 37-47出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1006/smim.2001.0340
关键词
SHIP; inositol phosphatase; inhibitory signaling; PIP3; Fc gamma RIIB1
类别
资金
- NIAID NIH HHS [AI-43425] Funding Source: Medline
Multiple lines of experimental data indicate that SHIP1 is an important negative regulator of the immune system. SHIP1 has been demonstrated to control survival and Proliferation, as well as differentiation. In the cases of some inhibitory receptors, such as Fcgamma RIIB1, the molecular mechanisms of control by SHIP1 are established. For other receptors, particularly activating receptors where SHIP1 appears to set activation thresholds, the mechanisms remain to be discovered. Further study on SHIP and other SHIP family members could be critical for our understanding the negative regulation in multiple hematopoietic lineages and the immune system as a whole.
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