期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 46, 期 2, 页码 528-530出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.46.2.528-530.2002
关键词
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A mixed culture of an hypermutable hexA Streptococcus pneumoniae mutant strain and its hex4 isogenic ancestor was challenged with low cefotaxime concentrations. Despite identical original cefotaxime MICs, the hexA mutant population was significantly selected at very low concentrations, and all of the tested selected variants harbored the Thr550-->Ala mutation in pbp2x. Since cefotaxime selects hypermutators, the risk of secondary acquisition of antibiotic resistance is increased; as expected, the cefotaxime-resistant mutants had a mutation frequency 10 times higher in response to to ciprofloxacin. The present study presents a model (not necessarily reflecting the clinical setting) illustrating the risk of selection of mutators in the evolution of multiple resistance.
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