期刊
TRENDS IN PLANT SCIENCE
卷 7, 期 2, 页码 51-54出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S1360-1385(01)02191-4
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资金
- Biotechnology and Biological Sciences Research Council [BBS/E/C/00004156] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BBS/E/C/00004156] Funding Source: researchfish
Polyunsaturated fatty acids (PUFAs) are involved in determining the biophysical properties of membranes as well as being precursors for signalling molecules. C20+ PUFA biosynthesis is catalysed by sequential desaturation and fatty acyl elongation reactions. This aerobic biosynthetic pathway was thought to be taxonomically conserved, but an alternative anaerobic pathway for the biosynthesis of polyunsaturated fatty acids is now known to exist that is analogous to polyketide ;synthases (PKS). These novel PKS genes could be used to direct the synthesis of PUFAs in heterologous hosts, as well as exploiting the combinatorial chemistry of PKSs to make unusual fatty acids.
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