期刊
VISION RESEARCH
卷 42, 期 4, 页码 497-505出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0042-6989(01)00229-2
关键词
rhodopsin; arrestin; retinitis pigmentosa; apoptosis
资金
- NEI NIH HHS [R01 EY11534] Funding Source: Medline
Previously we have shown that a subset of visual transduction mutants in Drosophila melanogaster induce the formation of stable complexes between rhodopsin and arrestin. One such mutant is in a visual system-specific phospholipase C (PLC). The rhodopsin/arrestin complexes generated in PLC mutants induce massive retinal degeneration. Here we demonstrate that both arrestin and rhodopsin undergo light-dependent endocytosis in a PLC mutant background. Interestingly, the internalized rhodopsin is rapidly degraded, but the arrestin is fully stable. The data are discussed with respect to mechanisms of arrestin-mediated endocytosis and human retinal disease. (C) 2002 Elsevier Science Ltd, All rights reserved.
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