期刊
DEVELOPMENTAL CELL
卷 2, 期 2, 页码 195-206出版社
CELL PRESS
DOI: 10.1016/S1534-5807(02)00114-4
关键词
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资金
- NIGMS NIH HHS [GM49869] Funding Source: Medline
Polarization of the one-cell C. elegans embryo establishes the animal's anterior-posterior (a-p) axis. We have identified reduction-of-function anaphase-promoting complex (APC) mutations that eliminate a-p polarity. We also demonstrate that the APC activator cdc20 is required for polarity. The APC excludes PAR-3 from the posterior cortex, allowing PAR-2 to accumulate there. The APC is also required for tight cortical association and posterior movement of the paternal pronucleus and its associated centrosome. Depletion of the protease separin, a downstream target of the APC, causes similar pronuclear and a-p polarity defects. We propose that the APC/separin pathway promotes close association of the centrosome with the cortex which in turn excludes PAR-3 from the posterior pole early in a-p axis formation.
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