期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 16, 期 1, 页码 74-84出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/brbi.2000.0619
关键词
stress; glucocorticoids; bacterial infections; wound healing; mice; RU486; wound infection; staphylococcus aureus; beta-hemolytic Streptococcus
资金
- NIDCR NIH HHS [P50 DE13749-01] Funding Source: Medline
Psychological stress delays wound healing and decreases immune/inflammatory responses required for bacterial clearance. To determine if stress increase, the susceptibility to wound infection, female SKH-1 mice were subjected to restraint stress (RST) beginning 3 days prior to the placement of cutaneous wounds. Viable bacteria were quantified from harvested wounds. RST delayed healing by 30% and caused a 2- to 5-log increase in opportunistic bacteria (e.g., Staphylococcus aureus) when compared to wounds from control animal, (p < .05). By day 7, 85.4% of the wounds from RST mice had bacterial counts predictive of infection compared to 27.4% from control mice (p < .001). To assess the role of RST-induced glucocorticoids in bacterial clearance, mice were treated with the glucocorticoid receptor antagonist RU486. RU486 reduced opportunistic bacteria by nearly 1 log in wounds from RST mice (p < .05). Thus, stress impairs, bacterial clearance during wound healing, resulting in a significant increase in the incidence of opportunistic infection. (C) 2001 Elsevier Science (USA).
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