期刊
INSECT MOLECULAR BIOLOGY
卷 11, 期 1, 页码 79-86出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.0962-1075.2001.00311.x
关键词
Dermacentor; saliva; serotonin; histamine; lipocalin
To overcome the inflammatory response in its host, the cattle-feeding, brown ear tick secretes histamine-binding proteins into the feeding site. These proteins are beta-barrels with two internal binding sites: a high-affinity (H) site for histamine and a site (L) for which the natural ligand is unknown. Here we report a related protein (SHBP), secreted by a rodent- and cattle-feeding tick, that traps both histamine and serotonin. The histamine-binding H site is well conserved in SHBP, whereas residue changes in the L-like site are consistent with binding of the bulkier serotonin molecule. As histamine is a key inflammatory mediator in cattle, while serotonin takes on this role in rodents, the diversification of these tick proteins may reflect host adaptation.
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