期刊
IMMUNOLOGY LETTERS
卷 80, 期 2, 页码 133-138出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-2478(01)00319-4
关键词
allergen; anti-idiotypic antibodies; immunoglobulin E; complementary peptide; peptide epitope; bovine beta lactoglobulin; milk allergy; immunotherapy
类别
The concept Of Specific immune treatment against allergic diseases requires the development of antibodies capable of specifically neutralizing anti-allergen antibodies. The aim of the present study was to investigate whether a novel approach, consisting in raising anti-idiotypic blocking antibodies through peptide immunization, could be envisaged in the field of allergy. Using allergy to cow's milk as a model, we prepared polyclonal antibodies against a peptide that is complementary (i.e. hydropathically opposed) to a major epitope of bovine beta-lactoglobulin (BLG), one of the main allergens of bovine milk. Anti-complementary peptide antibodies were found to neutralize in vitro both well-characterized anti-BLG monoclonal antibodies from mice sensitized to BLG and anti-BLG IgE from two patients suffering from milk allergy. These results suggest a new strategy For the functional inhibition of specific disease-associated IgE that may be applicable to the specific treatment of various allergic disorders. (C) 2002 Published by Elsevier Science B.V.
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