期刊
NATURE CELL BIOLOGY
卷 4, 期 2, 页码 154-159出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb745
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- Fondazione Telethon Funding Source: Custom
Adaptors are heterotetrameric complexes that mediate the incorporation of cargo into transport vesicles by interacting with sorting signals present in the cytosolic domain of transmembrane proteins. Four adaptors, AP-1 (beta1, gamma, mu1A or mu1B, sigma1), AP-2 (beta2, alpha, mu2, sigma2), AP-3 (beta3, delta, mu3, sigma3) or AP-4 (beta4, epsilonc, mu4, sigma4), have been characterized(1,2). AP1 and AP-3 mediate sorting events at the level of the TGN and/or endosomes, whereas AP-2 functions in endocytic clathrin coated vesicle formation; no function is known so far for AP-4. Here, we show that AP-4 can bind different types of cytosolic signals known to mediate basolateral transport in epithelial cells. Furthermore, in MDCK cells with depleted mu4 protein levels, several basolateral proteins are mis-sorted to the apical surface, showing that AP-4 participates in basolateral sorting in epithelial cells.
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