期刊
HUMAN PATHOLOGY
卷 33, 期 2, 页码 253-258出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/hupa.2002.31301
关键词
hepatosplenic gamma delta-T-cell lymphoma; renal transplantation; posttransplant lymphoproliferative disorders
类别
Hepatosplenic gammadeltaT-cell lymphoma (HSTCL) is a rare extra-nodal T-cell non-Hodgkin's lymphoma (T-NHL) with only 46 well-documented cases in medical literature. Notably, a relatively high number of these case reports (15%) describe the occurrence of HSTCL after solid organ transplantation. We describe the case of a 45-year-old man who developed a leukemic HSTCL 5 years after renal transplantation and continous immunosuppression with cyclosporine A and prednisolone. After a rapid clinical course, the patient died and autopsy was performed. The malignant lymphocytes showed a natural killer-like gammadeltaT-cell phenotype (CD2(+), CD3(+), CD7(+), TCR gammadelta(+), CD56(+), TIA-1(+), CD4(-), CD8(-), and TCR alphabeta(-)) and infiltrated the sinusoids of liver and the red pulp of the spleen. Cytogenetically, an isochromosome 7q, trisomy 8, Y-loss, and a translocation t(1;4) was detectable. This case shows the difficulties of recognizing HSTCL early in the clinical course and underlines that all types of T-NHL, nodal as well as extranodal, have to be considered in the differential diagnosis of posttransplantation lymphoproliferative disorders. Moreover, HSTCL seems to occur as a specific late complication of solid organ transplantation. Copyright 2002, Elsevier Science (USA). All rights reserved.
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