期刊
PHARMACOLOGY & THERAPEUTICS
卷 93, 期 2-3, 页码 293-305出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0163-7258(02)00198-5
关键词
two-component signal transduction; virulence; antibiotic resistance
资金
- NIGMS NIH HHS [GM19416] Funding Source: Medline
Two-component signal transduction systems are central elements of the virulence and antibiotic resistance responses of opportunistic bacterial pathogens. These systems allow the bacterium to sense and respond to signals emanating from the host environment and to modulate the repertoire of genes expressed to allow invasion and growth in the host. The integral role of two-component systems in virulence and antibiotic sensitivity, and the existence of essential two-component systems in several pathogenic bacteria, suggests that these systems may be novel targets for antimicrobial intervention. This review discusses the potential use of two-component systems as targets for antimicrobial therapy against Gram-positive pathogens and the current status in the development of inhibitors specific for these systems. (C) 2002 Elsevier Science Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据