Capillary electrophoresis of platinum-group elements analytical, speciation and biochemical studies

A great deal of research has been carried out in recent years on developing high-efficiency capillary electrophoresis (CE) techniques that are able to separate rapidly and selectively ionic platinum metal species in a wide variety of their complexed forms. Using a range of illustrative examples, this review examines the potential and utilization of various CE separation approaches and detection modes in this expanding area. Also covered are CE procedures suitable for solving practical analytical problems and for platinum metal speciation purposes. Presenting a comprehensive treatise on the evolving practices of CE concerning platinum anticancer drugs-in particular, the examination of the stability of intact drugs, the separation and identification of products of their metabolism and interactions with biomolecules (including kinetic studies of the binding behavior)-this paper witnesses a welcome shift of the main research activities to those performed under physiological conditions. (C) 2002 Elsevier Science B.V. All rights reserved.