期刊
NUCLEAR MEDICINE AND BIOLOGY
卷 29, 期 2, 页码 191-197出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0969-8051(01)00298-0
关键词
glioma; hypoxia; animal model; FMISO; positron emission tomography
We have demonstrated that FMISO uptake is significantly higher in tumor tissue in the C6 intracerebral glioma rat model compared to normal brain, and that there is persisting hypoxia in gliomas independent of tumor size. FMISO uptake was observed homogeneously throughout viable glioma tissue in tumor sizes ranging from 2mm to almost 1cm. Quantitation of uptake of FMISO showed a tumor/brain ratio of 1.9 and a tumor/blood ratio of 2.6 at 2 hours post injection. (C) 2002 Elsevier Science Inc. All rights reserved.
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