期刊
JOURNAL OF PEDIATRICS
卷 140, 期 2, 页码 171-176出版社
MOSBY-ELSEVIER
DOI: 10.1067/mpd.2002.121381
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资金
- NHLBI NIH HHS [HL-56398] Funding Source: Medline
- NINDS NIH HHS [NS-27306] Funding Source: Medline
Objective: This case-control study of chronic lung disease (CLD) evaluated the hypothesis that chorioamnionitis promotes CLD and interacts with other risk factors for CLD, including mechanical ventilation and postnatal infection. Study design: We identified a population of 193 infants who met our case criteria for CLD whose birth weights were: 1500 g. These infants were matched 1: 1 with control infants for gestational age and hospital of birth. Results: Univariable analyses revealed decreased CLD risk associated with histologic chorioamnionitis and increased risk associated with mechanical ventilation >7 days and culture-documented sepsis. In multivariable analyses, infants were at greatest risk for CLD when they had exposure to both chorioamnionitis and either mechanical ventilation >7 days (odds ratio, 3.2; 95% confidence interval, 0.9-11) or postnatal infection (odds ratio, 2.9; 95% confidence interval, 1.1-7.4). Conclusions: We conclude that prolonged mechanical ventilation or postnatal infection increases the risk of CLD among surviving preterm infants and that these 2 factors interact with antenatal infection to further increase the risk of CLD.
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