期刊
MUSCLE & NERVE
卷 25, 期 2, 页码 293-296出版社
JOHN WILEY & SONS INC
DOI: 10.1002/mus.10022
关键词
autoimmune disease; dermatomyostitis; hepatitis; myasthenia gravis; myositis; thymoma
We report a 28-year-old woman with a history of chronic immune-mediated hepatitis, in whom the simultaneous manifestation of dermatomyositis and myasthenia gravis resulted in severe neck extensor weakness and subacute respiratory insufficiency, followed by proximal muscle weakness and external ophthalmoplegia. Radiological signs of a thymoma were absent. The distinguishing clinical, electrophysiological, and biopsy findings are discussed. We suggest that an underlying immunoregulatory disorder was present, explaining the occurrence of three rare immune-mediated diseases in one patient. (C) 2002 John Wiley Sons, Inc.
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