期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 79, 期 2, 页码 199-204出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0378-8741(01)00383-X
关键词
Kalopanax pictus; kalopanaxsaponin; rheumatoidal arthritis; Freund's adjuvant reagent; antinociceptive; LD50
In the present study, we have attempted to elucidate the active components for rheumatoidal arthritis using chloroform (CHCl3), ethylacetate (EtOAc) and n-butanol (BuOH) fractions of the methanol extract (MeOH) of Kalopanax pictus. Kalopanaxsaponin-A and -I (KPS-A and -I, hederagenin monodesmoside) were isolated from EtOAc fraction and kalopanaxsaponin-B, -H and -K (KPS-B, -H and -K, hederagenin bisdesmosides) obtained from BuOH fraction, respectively. MeOH extract, EtOAc fraction (250, 500 mg/kg, p.o.) and KPS-A and -I (5, 10, 20 mg/kg, i.p.) exhibited significant antinociceptive effects, which were determined by acetic acid-induced writhing test and hot plate test. On Freund's complete adjuvant reagent-induced rheumatoidal arthritis in rats, the administration of EtOAc fraction and KPS-A and -I inhibited edema, agglutination, vascular permeability and trypsin inhibitor. In addition, LD50 of the MeOH extract was shown to be 4.033 mg/kg. These results sua est that anti-rheumatoidal effects of K-PS-A and -I contribute to the inhibition of kinin formation by suppression of trypsin inhibitor activity. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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