期刊
TETRAHEDRON LETTERS
卷 43, 期 6, 页码 951-954出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(01)02302-4
关键词
2-arylbenzoxazoles; DDQ; oxidation; ion-exchange resin; solution phase; library
The Schiff base derived from the condensation of o-aminophenol with benzaldehydes was induced to undergo oxidative cyclization in the presence of DDQ. The resulting 2-arylbenzoxazoles were separated from the reduced DDQ byproduct by treatment of reaction mixture with a strongly basic ion-exchange resin. The applicability of this chemistry to spatially separate library synthesis is demonstrated by the preparation of a 352-member library. (C) 2002 Elsevier Science Ltd. All rights reserved.
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