期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 99, 期 3, 页码 1574-1579出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.032448299
关键词
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资金
- NIAID NIH HHS [AI41108, R01 AI041108] Funding Source: Medline
- NIDCR NIH HHS [R01 DE013244, DE13244] Funding Source: Medline
With the goal of identifying and characterizing traits of Enterococcus faecalis that play key roles in human disease, we identified an operon specifying synthesis of a capsular carbohydrate of the type most commonly expressed by clinical isolates. This surface-exposed carbohydrate consists of glycerol phosphate, glucose, and galactose residues, and its biosynthesis is encoded by a determinant that includes 11 ORFs. Insertional inactivation of genes in this pathway yielded mutants with enhanced susceptibility to phagocytic killing in vitro and compromised in the ability to persist in regional lymph nodes in vivo.
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