Studies toward the discovery of the next generation of antidepressants.: Part 2:: Incorporating a 5-HT1A antagonist component into a class of serotonin reuptake inhibitors

The design and synthesis of a novel series of indole derivatives (9) having dual 5-HT transporter reuptake and 5-HT1A antagonist activity are described. (C) 2002 Elsevier Science Ltd. All rights reserved.