Cytotoxicity of 6,16-disubstituted analogues of (-)-vincadifformine

Eight analogues of (-)-16-chloro-1-dehydro-6S-bromovincadifformine 1 were synthesized and evaluated for cytotoxicity in L1210 cell culture. None of the new compounds was more active than 1 but the modulation at C6, C16 and on the aromatic ring at C10 informs about structure-activity relationships within this series. (C) 2002 Elsevier Science Ltd. All rights reserved.