期刊
BRITISH JOURNAL OF CANCER
卷 86, 期 4, 页码 546-551出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6600132
关键词
dendritic cells; breast carcinoma; CD 1a; CMRF-44; CMRF-56; CD83; DC activation
类别
Low CD 1a-positive putative dendritic cell numbers in human breast cancer has recently been described and may explain the apparent 'poor immunogenicity' previously reported in breast cancer, Lite attention has been given to dendritic cell activation within the tumour microenvironment, which is another reason why the in-situ immune response may be severely deficient We have therefore examined CD 1 a expression as a marker for dendritic cells, together with CMRF-44 and -56 as markers of dendritic cell activation status, in 40 human breast cancers, The results demonstrate few or no CD1a-positive putative dendritic cells and minimal or no expression of the dendritic cell activation markers. Both dendritic cell number and dendritic cell activation appear substantially deficient in human breast cancers, regardless of tumour histological grade. (C) 2002 Cancer Research UK.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据