期刊
NEUROSCIENCE LETTERS
卷 319, 期 2, 页码 87-90出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)02537-X
关键词
capsaicin; VR1 receptor; neurofilament; cholera toxin; dorsal root ganglia; A delta-fibers; C-fibers
The expression of capsaicin (VR1) receptor by A-fiber primary afferent neurons has been investigated by double immunohistochemical staining with VR1 and 200 kD neurofilament (NF200; an A-fiber marker) antibodies, and by VR1 immunohistochemical staining in combination with cholera toxin 8 subunit (CTB; also an A-fiber marker) retrograde tracing. Approximately 30% of the VR1-positive dorsal root ganglion (DRG) neurons were NF200-positive. Intra-sciatic nerve injection of CTB labeled over 30% of the VR1-positive neurons in the L5 DRG. Size frequency distribution analysis revealed that these VR1 and NF200, or VR1 and CTB, double-labeled neurons were predominantly small and medium sized. These results suggest that capsaicin receptors are likely to be expressed by Adelta-fiber neurons as well as C-fiber neurons. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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