期刊
SCIENCE
卷 295, 期 5558, 页码 1294-1298出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1067765
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资金
- NIGMS NIH HHS [R01GM58017] Funding Source: Medline
The Nedd8 ubiquitin-like protein modification pathway regulates cell-cycle progression. Our analysis of Nedd8 requirements during Caenorhabditis elegans embryogenesis indicates that the cytoskeleton is another target. Nedd8 conjugation negatively regulated contractility of the microfilament-rich cell cortex during pronuclear migration and again during cytokinesis. The Nedd8 pathway also was required after meiosis to negatively regulate katanin, a microtubule-severing complex, permitting the assembly of a large mitotic spindle. We propose that Nedd8-modified cullin, as part of an E3 ubiquitin ligase complex, targets katanin for degradation during the transition from meiosis to mitosis.
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