期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 291, 期 1, 页码 124-129出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/bbrc.2002.6393
关键词
capsaicin; proton; VR1; keratinocytes; intracellular Ca2+ concentration; capsazepine
Vanilloid receptor subtype 1, VR1, is an ion channel that serves as a polymodal detector of pain-producing chemicals such as capsaicin and protons in primary afferent neurons. Here we showed that both capsaicin and acidification produced elevations in the intracellular Ca2+ concentration ([Ca2+](i)) in cultured human epidermal keratinocytes. The capsaicin- and acidification-evoked increases in [Ca2+](i) were inhibited by capsazepine, an antagonist to VR1. VR1-like immunoreactivity was observed in the cells. These findings suggest that functional VR1-like protein is present and functions as a sensor against noxious chemical stimuli, such as capsaicin or acidification, in epidermal keratinocytes. (C) 2002 Elsevier Science (USA).
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