期刊
EMBO JOURNAL
卷 21, 期 4, 页码 685-693出版社
WILEY
DOI: 10.1093/emboj/21.4.685
关键词
cell division; cytokinesis; FtsZ; Z ring
资金
- NIGMS NIH HHS [R37 GM029764, GM 29764, R01 GM029764] Funding Source: Medline
ZipA and FtsA are essential division proteins in Escherichia coli that are recruited to the division site by interaction with FtsZ. Utilizing a newly isolated temperature-sensitive mutation in ZipA we have more fully characterized the role of ZipA. We confirmed that ZipA is not required for Z ring formation; however, we found that ZipA, like FtsA, is required for recruitment of FtsK and therefore all downstream division proteins. In the absence of FtsA or ZipA Z rings formed; however, in the absence of both, new Z rings were unable to form and preformed Z rings were destabilized. Consistent with this, we found that an FtsZ mutant unable to interact with both ZipA and FtsA was unable to assemble into Z rings. These results demonstrate that ZipA and FtsA are both required for recruitment of additional division proteins to the Z ring, but either one is capable of supporting formation and stabilization of Z rings.
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