期刊
FEBS LETTERS
卷 513, 期 1, 页码 77-84出版社
WILEY
DOI: 10.1016/S0014-5793(01)03308-7
关键词
FYVE domain; phosphatidylinositol 3-kinase; phosphoinositide; membrane traffic; signal transduction
The FYVE zinc finger domain is conserved from yeast (five proteins) to man (27 proteins). It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is found mainly on endosomes. Here we review recent work that sheds light on the targeting of FYVE finger proteins to PI3P-containing membranes, and how these proteins serve to regulate multiple cellular functions. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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