期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 233, 期 1-2, 页码 149-157出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-5173(01)00936-X
关键词
emulsion; nanoparticles; magnetite; magnetophoresis
This paper describes the preparation of colloidal lipid particles containing magnetite from warm emulsions. A two step method was used to obtain the nanoparticles: (i) formulation of a transparent phase by heating a O/W emulsion (aqueous surfactant solution melted with a lipid phase, containing the ethyl oleate and soybean lecithin) in which modified lipophilic magnetite is incorporated, and (ii) preparation of the nanoparticles by dispersing the warm transparent phase in cold water (7 degreesC) under mechanical stirring. The latter method gives spherical nanoparticles of a mean size of 62 nm measured by Photon Correlation Spectroscopy and Transmission Electronic Microscopy. The magnetite entrapment efficiency was determined by use of a magnetophoretic sedimentation method. (C) 2002 Elsevier Science B.V. All rights reserved.
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