期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 437, 期 3, 页码 151-154出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(02)01307-9
关键词
adenosine A(1) receptor; cortex, posterior cingulate; short-term memory; long-term memory
Male Wistar rats were bilaterally implanted with indwelling cannulae in the caudal region of the posterior cingulate cortex. After recovery, animals were trained in a step-down inhibitory avoidance task (3.0-s, 0.4-mA foot shock) and received, immediately after training, a 0.5-mul infusion of the adenosine A(1) receptor agonist N6-cyclopentyladenosine (CPA; 1, 50 or 100 nM) or of the adenosine A(1) receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX; 1, 25 or 50 nM). Animals were tested twice, 1.5 h and, again, 24 h after training, in order to examine the effects of these agents on short- and long-term memory, respectively. Only 50-nM DPCPX was effective in altering memory, promoting a facilitation. These results suggest that adenosine A(1) receptors in the posterior cingulate cortex inhibit memory consolidation in a way that their blockade facilitates memory for inhibitory avoidance in rats. (C) 2002 Elsevier Science B.V. All rights reserved.
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