期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 187, 期 1-2, 页码 173-178出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0303-7207(01)00695-5
关键词
cytostatic factor; oocyte maturation; MAPK; Bub1; Rsk; spindle assembly checkpoint
资金
- NIDDK NIH HHS [DK28353] Funding Source: Medline
- NIGMS NIH HHS [GM26743] Funding Source: Medline
A cytoplasmic activity in mature oocytes responsible for second meiotic metaphase arrest was identified over 30 years ago in amphibian oocytes. In Xenopus oocytes cytostatic factor (CSF) activity is initiated by the progesterone-dependent synthesis of Mos, a MAPK kinase kinase that activates the MAPK pathway. CSF arrest is mediated by a sole MAPK target, the protein kinase p90(Rsk). Rsk phosphorylates and activates the Bub1 protein kinase, which may cause metaphase arrest due to inhibition of the anaphase-promoting complex (APC) by a conserved mechanism defined genetically in yeast and mammalian cells. CSF arrest in vertebrate oocytes by p90(Rsk) provides a link between the MAPK pathway and the spindle assembly checkpoint in the cell cycle. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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