期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 12, 期 4, 页码 709-713出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(01)00839-3
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Metabolites of the non-steroidal anti-inflammatory drug Sulindac inhibit cell proliferation by affecting several intracellular signaling pathways including the tumorigenic Ras/Raf/MAPK pathway. Here, we report the synthesis of eight new indene derivatives derived from the Sulindac structure, and present data on their anti-proliferative properties and their effects on the p21ras protein. (C) 2002 Elsevier Science Ltd. All rights reserved.
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