期刊
AUSTRALIAN JOURNAL OF CHEMISTRY
卷 65, 期 3, 页码 266-274出版社
CSIRO PUBLISHING
DOI: 10.1071/CH11432
关键词
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资金
- A-STAR Institute of Materials Research and Engineering
- Ministry of Higher Education of Saudi Arabia
- Cancer and Polio Research Fund
- North West Cancer Research Fund
An important feature necessary for biological stability of gold nanoparticles is resistance to ligand exchange. Here, we design and synthesize self-assembled monolayers of mixtures of small ligands on gold nanoparticles promoting high resistance to ligand exchange. We use as ligands short thiolated peptidols, e.g. H-CVVVT-ol, and ethylene glycol terminated alkane thiols (HS-C-11-EG(4)). We present a straightforward method to evaluate the relative stability of each ligand shell against ligand exchange with small thiolated molecules. The results show that a ligand with a 'thin' stem, such as HS-C-11-EG(4), is an important feature to build a highly packed self-assembled monolayer and provide high resistance to ligand exchange. The greatest resistance to ligand exchange was found for the mixed ligand shells of the pentapeptidols H-CAVLT-ol or H-CAVYT-ol and the ligand HS-C-11-EG(4) at 30:70 (mole/mole). Mixtures of ligands of very different diameters, such as the peptidol H-CFFFY-ol and the ligand HS-C-11-EG(4), provide only a slightly lower stability against ligand exchange. These ligand shells are thus likely to be suitable for long-term use in biological environments. The method developed here provides a rapid screening tool to identify nanoparticles likely to be suitable for use in biological and biomedical applications.
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