期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 195, 期 1, 页码 85-91出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0022-510X(01)00689-X
关键词
dementia with Lewy bodies; neurofibrillary tangle; Lewy body; tau; alpha-synuclein; hippocampus; perforant pathway; formation process
Using tau immunohistochemistry and alpha-synuclein immunohistochemistry, we quantitatively investigated the most frequent sites and the formation process of neurofibrillary tangles (NFT) and Lewy bodies (LB) in the hippocampus from 20 patients with dementia with Lewy bodies (DLB). NFT were most frequently found in the CA2 and the subiculutn-pre-CA1, while LB were most frequently found in the CA3-4 and the subiculum-pre-CA1. In the intrahippocampal routes of the perforant pathway, tau immunoelectron microscopy demonstrated distal axons containing aggregated tau-positive microtubules, while alpha-synuclein immunoelectron microscopy revealed terminal axons containing aggregated alpha-synuclein-positive tubular or filamentous components. These findings suggest that NFT and LB are first formed in the CA2 and the CA3-4 related to degeneration of the nonperforating route of the perforant pathway, respectively, and subsequently in the subiculum-pre-CA1 chiefly related to degeneration of the perforating route. Coexistence of NFT and LB in the same neurons was found most frequently in the subiculum-pre-CA1. In addition, coexistence of tau and alpha-synuclein was found in terminal axons of the perforant pathway, and tau accumulated not in paired helical filaments but in the periphery of alpha-synuclein-positive components immunoelectronmicroscopically, suggesting that alpha-synuclein stimulates the accumulation of phosphorylated tau in terminal axons. (C) 2002 Elsevier Science B.V All rights reserved.
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