期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 539, 期 3, 页码 707-712出版社
WILEY
DOI: 10.1113/jphysiol.2001.015024
关键词
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资金
- NIMH NIH HHS [MH 10474, P50 MH045156, MH 45156, F31 MH010474] Funding Source: Medline
We have employed in vitro physiological methods to investigate dopaminergic modulation of excitatory synaptic transmission in monkey prefrontal cortex (PFC) circuits. We show that combined activation of D1-like and D2-like dopamine receptors results in the reduction of extracellular stimulation-evoked isolated EPSCs in layer 3 pyramidal neurons. Using paired recordings from synaptically connected pyramidal neurons we have determined the basic properties of unitary synaptic connections between layer 3 pyramids in the primate PFC and, interestingly, we found that dopamine does not reduce synaptic transmission between nearby pairs of synaptically coupled PFC pyramidal neurons. This input specificity maybe a critical aspect of the dopaminergic regulation of recurrent excitatory circuits in the PFC.
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