期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 195, 期 6, 页码 737-745出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20011626
关键词
B lymphocyte subsets; antibody formation; cell differentiation; cell lineage; immunophenotyping
资金
- NIAID NIH HHS [AI 26296, R01 AI026296, R37 AI026296] Funding Source: Medline
The contribution that long-lived bone marrow (BM) plasma cells (PCs) provide to enduring humoral immunity has been underscored by a number of recent studies. However, little is known about the immediate precursors that give rise to long-lived PCs in the BM of immune individuals. We have identified subsets of antigen-experienced B cells within the immune BM that are precursors to PCs. These PC precursors arise in the BM 14 days after immunization and persist for greater than 9 months. Phenotypically distinct subsets of PC precursors give rise to short-lived or long-lived PCs. The differentiation of PC precursors to PCs occurs in the absence of antigen and requires cell division. The functional significance of these newly identified PC precursors in the persistence and quality of the humoral immune response is discussed.
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