期刊
NEUROREPORT
卷 13, 期 4, 页码 497-500出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200203250-00028
关键词
ARC; beta-END; feeding; alpha-MSH; PVN; POMC
资金
- NIDA NIH HHS [DA-03999] Funding Source: Medline
- NIDDK NIH HHS [P30-DK-50456] Funding Source: Medline
beta-Endorphin (beta-END) and alpha-melanocyte stimulating hormone (alpha-MSH), neuropeptides derived from proopiomelanocortin (POMC), have opposite effects on eating behavior. We injected rats with alpha-MSH (0.6 nmol) or beta-END (1 nmol) into the PVN (three times in a 26 h period). These doses of alpha-MSH and beta-END decreased and increased feeding respectively. Following alpha-MSH administration into the PVN, m RNA levels of POMC decreased by 17%, whereas there was no significant change in gene expression of either proDynorphin or proEnkephalin. PVN injection of beta-END failed to alter gene expression of POMC, proDynorphin or proEnkephalin. These data suggest that a feedback pathway exists between the PVN and ARC for alpha-MSH and POMC, but not for beta-END and POMC.
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