期刊
TETRAHEDRON
卷 58, 期 13, 页码 2673-2680出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(02)00115-1
关键词
N-trityl; thiazolidine; peptide aldehyde; solid phase; ligation
Chiral N-methyl thiazolidines masked alpha-amino aldehydes are used for solid phase peptide aldehyde elongation. Contrary to N-Boc-protected alpha-amino aldehydes, N-trityl protection secures the chiral integrity of the incoming aldehyde chiral Cl' carbon atom during condensation of the amino aldehydes with L-cysteinyl residues. The Ac-Tyr-Val-Ala-Asp-H caspase inhibitor was prepared on a solid support starting from the N-trityl-amino thiazolidine masked aspartinal as a validation of this process. (C) 2002 Elsevier Science Ltd. All rights reserved.
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