期刊
PEPTIDES
卷 23, 期 4, 页码 807-816出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0196-9781(01)00666-0
关键词
aging; Caenorhabditis elegans; cell size; Drosophila melanogaster; growth; hormone; invertebrate; metabolism; obesity; peptide; receptor; reproduction
The 'insulin superfamily' is an ancient category of small, structurally related proteins, such as insulin, insulin-like growth factors (IGF) and relaxin. Insulin-like signaling molecules have also been described in different invertebrates, including nematodes, mollusks, and insects. They initiate an evolutionary conserved signal transduction mechanism by binding to a heterotetrameric, membrane-spanning receptor tyrosine kinase. Recent physiological and genetic studies have revealed that, in different metazoans, the insulin signaling pathway plays a pivotal role in the regulation of a variety of interrelated, fundamental processes, such as metabolism, growth, reproduction and aging. (C) 2002 Elsevier Science Inc. All rights reserved.
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