期刊
BLOOD
卷 99, 期 7, 页码 2617-2619出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood.V99.7.2617
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- NCI NIH HHS [CA 68221, CA 16042] Funding Source: Medline
- NIAID NIH HHS [AI 07126-25] Funding Source: Medline
Cyclic adenosine monophosphate response-element binding protein (CREB) is a nuclear protein that regulates expression of genes that control cell proliferation, differentiation, and survival. To analyze CREB expression in leukemia cells, we conducted Western blot analysis of bone marrow cells obtained from patients with acute lymphoblastic leukemia:, patients with acute myeloid leukemia, and patients without active, leukemia. CREB was expressed at a higher frequency in bone marrow cells from patients with acute lymphoid or myeloid leukemia than in patients with leukemia remission or without leukemia. Our results indicate that CREB expression could be a useful marker for leukemia In patients with acute disease and suggest a role for CREB in leukemogenesis. (C) 2002 by The American Society of Hematology.
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