期刊
VISION RESEARCH
卷 42, 期 9, 页码 1081-1087出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0042-6989(02)00032-9
关键词
GABAc receptor; b-wave; amacrine cell; ERG; rabbit
The electroretinogram b-wave is generally believed to reflect mainly light-induced activity of ON-center bipolar cells and Muller cells. Recently, there is increasing evidence that third-order retinal neurons can also contribute significantly to the b-wave. In a previous study (Vis. Res. 40 (2000) 579) we proposed that the GABAc feedback from amacrine cells to bipolar cells call affect both the amplitude and kinetics of the b-wave. Here we show that blocking this feedback has profound effects on b-wave amplitude and kinetics. These results demonstrate that feedback to bipolar cells is an important mechanism through which amacrine cells contribute to b-wave generation. Our results also provide functional evidence that the feedback may be involved in temporal processing in the mammalian retina. (C) 2002 Elsevier Science Ltd. All rights reserved.
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