期刊
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
卷 19, 期 4, 页码 261-268出版社
ELSEVIER
DOI: 10.1016/S0924-8579(02)00022-5
关键词
pharmacokinetic/pharmacodynamic; antimicrobials; pathogens
Animals have been extensively used in the evaluation of antimicrobials. The value of animals in the pharmacokinetic and pharmacodynamic characterization of antimicrobials is critically reviewed. Animal studies have demonstrated that the pharmacokinetic/pharmacodynamic (PK/PD) target determining efficacy can vary for different classes of antimicrobials. However, the magnitude of the target required for bacteriological efficacy is relatively similar for various sites of infection, various pathogens and various drugs within the same class, provided free drug levels are used. (C) 2002 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.
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