期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 66, 期 4, 页码 705-710出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.66.705
关键词
phthalic acid ester; di(2-ethylhexyl)phthalate; conversion ratio of tryptophan to niacin; endocrine disrupter; niacin toxicity
We have previously reported that the administration of a large amount of di(n-butyl)phthalate (DBP) increased the conversion ratio of tryptophan to niacin in rats. In the present experiment, the effect of di(2-ethylhexyl)phthalate (DEHP) on the conversion ratio and how altering the conversion ratio of tryptophan to niacin depended on the concentration of DEHP were investigated to elucidate the toxic mechanism of phthalic acid esters (PhE). Rats were fed with a diet containing 0%, 0.01 %, 0.05 %, 0.1 %, 0.5 %, 1.0 %, or 3.0 % DEHP for 21 days. To assess the conversion ratio of tryptophan to niacin, urine samples were collected at the last day of the experiment and measured for metabolites on the tryptophan-niacin pathway. The conversion ratio increased with increasing dietary concentration of DEHP above 0.05 %; the conversion ratio was about 2 % in the control group, whereas it was 28 % in the 3.0 % DEHP group. It is suggested that the inhibition of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) by DEHP or its metabolites caused this increase in the conversion ratio. We conclude that PhE such as DEHP and DBP disturbed the tryptophanniacin metabolism.
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