期刊
REGULATORY TOXICOLOGY AND PHARMACOLOGY
卷 35, 期 2, 页码 217-226出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/rtph.2001.1523
关键词
MMVF; stone wool; HT fiber; in vivo biopersistence; in vitro dissolution; glass structure; pH 4.5; CAS No. 287922-11-6
Man-made vitreous fibers (MMVF) are classified within the European Union (EU) as carcinogenic category 3 (possibly carcinogenic), but criteria exist to exonerate fibers from this classification. The HT stone wool fiber type is a MMVF that fulfills European regulatory requirements for exoneration from classification as a carcinogen based on in vivo testing. The chemical composition of the fibers and the results of the in vivo and in vitro studies that defined the chemical compositional range for a CAS registry number for these fibers are presented and discussed. Results from in vitro dissolution measurements at pH 4.5 of 52 fiber compositions (9-23 wt% Al2O3 and 32-47 wt% SiO2) ranging from traditional stone wool to the biosoluble HT fibers are presented. The results are evaluated as a function of the ratio Al/(Al + Si) in the glass network and as a function of the fraction of Si-O-Si linkages in the glass. It is suggested that the dissolution mechanism for these fibers relates to the density of the surface silica layer on dissolving fibers and that the fraction of Si-O-Si linkages influences this. (C) 2002 Elsevier Science (USA).
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