期刊
BIOMATERIALS
卷 23, 期 7, 页码 1649-1656出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0142-9612(01)00291-5
关键词
microspheres; dexamethasone; continuous release; PLGA; implant; biosensor; anti-inflammatory
资金
- NCRR NIH HHS [1R01RR14171] Funding Source: Medline
The purpose of this research was to develop polylactic-co-glycolic acid (PLGA) microspheres for continuous delivery of dexamethasone for over a 1-month period. in in effort to suppress the acute and chronic inflammatory reactions to implants such as biosensors, which interfere with their functionality. The microspheres were prepared using an oil-in-water emulsion technique. The oil phase was composed of 9:1 dichloromethane to methanol with dissolved PLGA and dexamethasone. Some microspheres were predegraded for 1 or 2 weeks. Ten percent of polyethylene glycol was added to the oil phase in alternative Formulations to delay drug release. The in vitro release Studies were performed in a constant temperature (37degreesC) warm room, in phosphate-buffered saline at sink conditions. Drug loading and release rates were determined by HPLC-UV analysis. The standard microsphere systems did not provide the desired release profile since, following an initial burst release, a delay of 2 weeks occurred prior to continuous drug release. Predegraded microspheres started to release dexamethasone immediately but the rate of release decreased after only 2 weeks. A mixed standard and predegraded microsphere system was used to avoid this delay and to provide continuous release of dexamethasone for 1 month. (C) 2002 Elsevier Science Ltd. All rights reserved.
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