期刊
JOURNAL OF IMMUNOLOGY
卷 168, 期 7, 页码 3288-3294出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.168.7.3288
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资金
- NCI NIH HHS [CA85580] Funding Source: Medline
- NIAID NIH HHS [AI44160, AI44259, AI10207] Funding Source: Medline
Thymic stromal lymphopoietin (TSLP) is a cytokine that facilitates B lymphocyte differentiation and costimulates T cells. Previous studies have demonstrated that a functional TSLP receptor complex is a heterodimer consisting of the TSLP receptor and the IL-7R alpha-chain. TSLP-mediated signaling is unique among members of the cytokine receptor family in that activation of the transcription factor Stat5 occurs without detectable Janus kinase activation. Using a variety of biological systems we demonstrate here that TSLP-mediated Stat5 activation can be uncoupled from proliferation. We also show that the single tyrosine residue in the cytoplasmic domain of the TSLP receptor is critical for TSLP-mediated proliferation, but is dispensable for Stat5 activation. Our data demonstrate that TSLP-mediated Stat5 activation is insufficient for cell proliferation and identifies residues within the TSLP receptor complex required to mediate these downstream events.
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